Allostatic load - a challenge to measure multisystem physiological dysregulation
نویسندگان
چکیده
Allostatic load is a sub-clinical dysregulation state, resulting from the body’s response to stress. Allostatic load accumulates gradually over the life course and affects a number of physiological systems. Measuring multisystem dysregulation and changes in it over time is very challenging. In this paper, we discuss composite measures used to capture allostatic load and the challenges involved in deriving and using these measures. Our focus is on measuring allostatic load in later life.
منابع مشابه
Allostatic Load and Health in the Older Population of England: A Crossed-Lagged Analysis
OBJECTIVE Allostatic load, a composite measure of accumulated physical wear and tear, has been proposed as an early sign of physiological dysregulation predictive of health problems, functional limitation, and disability. However, much previous research has been cross sectional and few studies consider repeated measures. We investigate the directionality of associations between allostatic load,...
متن کاملThe Authors Reply: Pursuing the Optimal Operationalization of Allostatic Load.
1. Wiley JF, Gruenewald TL, Karlamangla AS, Seeman TE. Modeling multisystem physiological dysregulation. Psychosom Med 2016;78:290–301. 2. Booth T, Starr JM, Deary I. Modeling multisystem biological risk in later life: allostatic load in the Lothian Birth Cohort study 1936. Am J Hum Biol 2013;25: 538–43. 3. Seeman T, Gruenewald T, Karlamangla A, Sidney S, Liu K, McEwen B, Schwartz J. Modeling m...
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OBJECTIVE Increasing evidence suggests that chronic exposure to unfair treatment or day-to-day discrimination increases risk for poor health, but data on biological stress mechanisms are limited. This study examined chronic experiences of unfair treatment in relation to allostatic load (AL), a multisystem index of biological dysregulation. METHOD Data are from a sample of 233 African-American...
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Background Discrimination promotes multisystem physiological dysregulation termed allostatic load, which predicts morbidity and mortality. It remains unclear whether weightrelated discrimination influences allostatic load. Purpose The aim of this study was to prospectively examine 10-year associations between weight discrimination, allostatic load, and its components among adults 25–75 years in...
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